Main page (Russian)
Search in database (English)
Properties of substance:
acetaminophen
skc-file
Synonyms:
p-hydroxyacetanilide
paracetamol
Group of substances:
organic
Physical appearance:
white monoclinic crystals
Empirical formula (Hill's system for organic substances):
C
8
H
9
NO
2
Structural formula as text:
HOC6H4NHCOCH3
Molar/atomic mass: 151.163
Melting point (°C):
168
CAS №: 103-90-2
Solubility (g/100 g of solvent):
1,2-dichloroethane
: soluble [
Ref.
]
1,4-dioxane
: 1.708 (30°C) [
Ref.
]
1-butanol
: 4.755 (-5°C) [
Ref.
]
1-butanol
: 5.196 (0°C) [
Ref.
]
1-butanol
: 5.721 (5°C) [
Ref.
]
1-butanol
: 6.331 (10°C) [
Ref.
]
1-butanol
: 6.929 (15°C) [
Ref.
]
1-butanol
: 7.707 (20°C) [
Ref.
]
1-butanol
: 8.327 (25°C) [
Ref.
]
1-heptanol
: 3.743 (30°C) [
Ref.
]
1-hexanol
: 4.971 (30°C) [
Ref.
]
1-octanol
: 2.747 (30°C) [
Ref.
]
1-pentanol
: 6.782 (30°C) [
Ref.
]
1-propanol
: 7.23 (0°C) [
Ref.
]
1-propanol
: 10.809 (20°C) [
Ref.
]
1-propanol
: 13.277 (30°C) [
Ref.
]
2-propanol
: 1.719 (0°C) [
Ref.
]
2-propanol
: 10.878 (20°C) [
Ref.
]
2-propanol
: 13.501 (30°C) [
Ref.
]
acetic acid
: 8.272 (30°C) [
Ref.
]
acetone
: 5.039 (-5°C) [
Ref.
]
acetone
: 5.561 (0°C) [
Ref.
]
acetone
: 6.232 (5°C) [
Ref.
]
acetone
: 6.963 (10°C) [
Ref.
]
acetone
: 7.848 (15°C) [
Ref.
]
acetone
: 8.809 (20°C) [
Ref.
]
acetone
: 9.938 (25°C) [
Ref.
]
acetone
: 11.165 (30°C) [
Ref.
]
acetonitrile
: 1.118 (0°C) [
Ref.
]
acetonitrile
: 2.31 (20°C) [
Ref.
]
acetonitrile
: 3.283 (30°C) [
Ref.
]
benzene
: practically insoluble [
Ref.
]
carbon tetrachloride
: 0.089 (30°C) [
Ref.
]
chloroform
: 0.154 (30°C) [
Ref.
]
diethyl ether
: practically insoluble [
Ref.
]
dimethylformamide
: 101.202 (30°C) [
Ref.
]
dimethylsulfoxide
: 113.256 (30°C) [
Ref.
]
ethanol
: 11.856 (-5°C) [
Ref.
]
ethanol
: 12.965 (0°C) [
Ref.
]
ethanol
: 15.614 (10°C) [
Ref.
]
ethanol
: 19.061 (20°C) [
Ref.
]
ethanol
: 23.275 (30°C) [
Ref.
]
ethyl acetate
: 0.527 (0°C) [
Ref.
]
ethyl acetate
: 0.852 (20°C) [
Ref.
]
ethyl acetate
: 1.073 (30°C) [
Ref.
]
ethylene glycol
: 14.43 (30°C) [
Ref.
]
hexane
: 0.000719 (25°C) [
Ref.
]
methanol
: 19.148 (0°C) [
Ref.
]
methanol
: 23.96 (10°C) [
Ref.
]
methanol
: 29.781 (20°C) [
Ref.
]
methanol
: 37.161 (30°C) [
Ref.
]
methyl ethyl ketone
: 6.999 (30°C) [
Ref.
]
methylene chloride
: 0.032 (30°C) [
Ref.
]
pentane
: practically insoluble [
Ref.
]
petroleum ether: practically insoluble [
Ref.
]
tetrahydrofuran
: 15.537 (30°C) [
Ref.
]
toluene
: 0.022 (0°C) [
Ref.
]
toluene
: 0.037 (20°C) [
Ref.
]
toluene
: 0.034 (30°C) [
Ref.
]
water
: 1.436 (25°C) [
Ref.
]
water
: 2.72 (50°C) [
Ref.
]
Density:
1.293 (21°C, d
4
)
Reactions:
Yeild 90%. [
Ref.1
]
CH
3
CONHC
6
H
4
OH + CH
2
=CHCH
2
Br → CH
3
CONHC
6
H
4
OCH
2
CH=CH
2
+ HBr
Dissociation:
pK
a
(1) = 9.5 (25°C, water)
LD
50
(mg/kg):
2404 (rats, oral)
338 (mice, oral)
Spectral properties of the substance:
Ultraviolet/visible spectrum (maximum in nm, layer thickness 1 cm, in parentheses - extinction) = 250 (138)
Ultraviolet/visible spectrum (maximum in nm, layer thickness 1 cm, in parentheses - extinction) = 257
Ultraviolet/visible spectrum (maximum in nm, layer thickness 1 cm, in parentheses - extinction) = 245
References:
Clarke's Analysis of Drugs and Poisons. - 4 ed. - London, 2011. - pp. 1856-1858
Dictionary of organic compounds. - Vol. 2, Eccaine - Myrtillin chloride. - London, 1946. - pp. 213
Jouyban A. Handbook of solubility data for pharmaceutacals. – CRC Press, 2010. - pp. 71-220
Kleemann A. Pharmaceutical Substances. - 2000. - pp. 1557-1558
Milne G.W.A. Gardner's Commercially Important Chemicals. - Wiley-Interscience, 2005. - pp. 5-6
The Merck Index 11th ed., Merck & Company, 1989. - pp. 8
Yalkowsky S.H., Yan H. Handbook of aqueous solubility data. - CRC Press, 2003. - pp. 487
Беликов В.Г. Учебное пособие по фармацевтической химии. - М.: Медицина, 1979. - pp. 183 [Russian]
Максютина Н.П., Каган Ф.Е. и др. Методы идентификации фармацевтических препаратов. - Киев: Здоров'я, 1978. - pp. 22, 28 [Russian]
Машковский М.Д. Лекарственные средства. - 14-е изд., Т. 1. - М.: Новая волна, 2002. - pp. 161-162 [Russian]
Неотложная помощь при острых отравлениях: Справочник по токсикологии. - Под ред. Голикова С.Н. - М.: Медицина, 1977. - pp. 146 [Russian]
Справочник химика. - Т. 6. - Л.: Химия, 1967. - pp. 838-839 [Russian]
Химический энциклопедический словарь. - Под ред. Кнунянц И.Л. - М.: Советская энциклопедия, 1983. - pp. 423 [Russian]
What information do you need?
© Collected Ruslan Anatolievich Kiper, burewestnik@mail.ru