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Properties of substance:
2,5-dihydroxybenzoic acid
Synonyms:
gentisic acid
Group of substances:
organic
Physical appearance:
crystals
Empirical formula (Hill's system for organic substances):
C
7
H
6
O
4
Structural formula as text:
(HO)2C6H3COOH
Molar/atomic mass: 154.12
Melting point (°C):
205
Decomposition temperature (°C):
205
CAS №: 490-79-9
Solubility (g/100 g of solvent):
benzene
: insoluble [
Ref.
]
carbon disulphide
: insoluble [
Ref.
]
chloroform
: sparingly soluble [
Ref.
]
diethyl ether
: very soluble [
Ref.
]
ethanol
: very soluble [
Ref.
]
water
: 0.83 (0°C) [
Ref.
]
water
: 2.2 (25°C) [
Ref.
]
Dissociation:
pK
a
(1) = 2.97 (25°C, water)
pK
a
(2) = 10.5 (25°C, water)
LD
50
(mg/kg):
4500 (mice, oral)
374 (mice, intravenous)
References:
Catalog handbook of fine chemicals Aldrich, 1992-1993. - pp. 461
Dictionary of organic compounds. - Vol. 2, Eccaine - Myrtillin chloride. - London, 1946. - pp. 108
Journal of Physical and Chemical Reference Data. - 2013. - Vol. 42, No. 3. - pp. 033103-262 - 033103-263
Kleemann A. Pharmaceutical Substances. - 2000. - pp. 959-960
Seidell A. Solubilities of organic compounds. - 3ed., vol.2. - New York: D. Van Nostrand Company, 1941. - pp. 531
Stahl P.H., Wermuth C.G. Handbook of Pharmaceutical Salts: Properties, Selection, and Use. - Wiley-VCH, 2002. - pp. 283-284
The Merck Index 11th ed., Merck & Company, 1989. - pp. 688
Yalkowsky S.H., Yan H. Handbook of aqueous solubility data. - CRC Press, 2003. - pp. 378
Халецкий А.М. Фармацевтическая химия. - Л.: Медицина, 1966. - pp. 171 [Russian]
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© Collected Ruslan Anatolievich Kiper, burewestnik@mail.ru