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Properties of substance:

2,5-dihydroxybenzoic acid

Synonyms:

gentisic acid

Group of substances:

organic

Physical appearance:

crystals

Empirical formula (Hill's system for organic substances):

C7H6O4

Structural formula as text:

(HO)2C6H3COOH

Molar/atomic mass: 154.12

Melting point (°C):

205

Decomposition temperature (°C):

205

CAS №: 490-79-9

Solubility (g/100 g of solvent):

benzene: insoluble [Ref.]
carbon disulphide: insoluble [Ref.]
chloroform: sparingly soluble [Ref.]
diethyl ether: very soluble [Ref.]
ethanol: very soluble [Ref.]
water: 0.83 (0°C) [Ref.]
water: 2.2 (25°C) [Ref.]

Dissociation:

pKa (1) = 2.97 (25°C, water)
pKa (2) = 10.5 (25°C, water)

LD50 (mg/kg):

4500 (mice, oral)
374 (mice, intravenous)

References:

  1. Catalog handbook of fine chemicals Aldrich, 1992-1993. - pp. 461
  2. Dictionary of organic compounds. - Vol. 2, Eccaine - Myrtillin chloride. - London, 1946. - pp. 108
  3. Journal of Physical and Chemical Reference Data. - 2013. - Vol. 42, No. 3. - pp. 033103-262 - 033103-263
  4. Kleemann A. Pharmaceutical Substances. - 2000. - pp. 959-960
  5. Seidell A. Solubilities of organic compounds. - 3ed., vol.2. - New York: D. Van Nostrand Company, 1941. - pp. 531
  6. Stahl P.H., Wermuth C.G. Handbook of Pharmaceutical Salts: Properties, Selection, and Use. - Wiley-VCH, 2002. - pp. 283-284
  7. The Merck Index 11th ed., Merck & Company, 1989. - pp. 688
  8. Yalkowsky S.H., Yan H. Handbook of aqueous solubility data. - CRC Press, 2003. - pp. 378
  9. Халецкий А.М. Фармацевтическая химия. - Л.: Медицина, 1966. - pp. 171 [Russian]

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    © Collected Ruslan Anatolievich Kiper, burewestnik@mail.ru