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Properties of substance:
clonidine hydrochloride
skc-file
Group of substances:
organic
Physical appearance:
white crystals
Empirical formula (Hill's system for organic substances):
C
9
H
1
0
Cl
3
N
3
Molar/atomic mass: 266.57
Melting point (°C):
314
Decomposition temperature (°C):
316
CAS №: 4205-91-8
Solubility (g/100 g of solvent):
chloroform
: 0.013 [
Ref.
]
diethyl ether
: practically insoluble [
Ref.
]
ethanol
: 5 [
Ref.
]
ethanol
: 20 (78°C) [
Ref.
]
ethanol abs.
: 2.6 [
Ref.
]
methanol
: 21.84 [
Ref.
]
water
: 7 (20°C) [
Ref.
]
water
: 16.6 (60°C) [
Ref.
]
water
: 50 (100°C) [
Ref.
]
LD
50
(mg/kg):
190 (, oral)
236 (, intraperitoneal)
126 (, oral)
21.2 (, intraperitoneal)
70 (, intraperitoneal)
192 (, oral)
60.3 (, oral)
166 (, intraperitoneal)
33.8 (, intraperitoneal)
135 (, oral)
24.7 (, oral)
104 (, intraperitoneal)
References:
Armarego W. L. F. Purification of Laboratory Chemicals. - 7ed. - 2013. - pp. 867
Clarke's Analysis of Drugs and Poisons. - 4 ed. - London, 2011. - pp. 1138-1140
Kleemann A. Pharmaceutical Substances. - 2000. - pp. 523
Lewis R.J. Sax's Dangerous Properties of Industrial Materials. - 12ed., Vol. 1-5. - Wiley, 2012. - pp. 1178
Mills T. III, Roberson J.C. Instrumental data for drug analysis. - 2 ed., vol.1, 1993. - pp. 514-515
Milne G.W.A. Gardner's Commercially Important Chemicals. - Wiley-Interscience, 2005. - pp. 151
Sittig M. Pharmaceutical Manufacturing Encyclopedia. - 2ed. - Westwood, 1988. - pp. 372-373
The Merck Index 11th ed., Merck & Company, 1989. - pp. 374
Вартанян Р.С. Синтез основных лекарственных средств. - М.: МИА, 2004. - pp. 218-219 [Russian]
Токсикологический вестник. - 1995. - №4. - pp. 9-11 [Russian]
Токсикологический вестник. - 1999. - №5. - pp. 35-36 [Russian]
Химическая энциклопедия. - Т. 2. - М.: Советская энциклопедия, 1990. - pp. 410 [Russian]
Яхонтов Л.Н., Глушков Р.Г. Синтетические лекарственные средства. - М.: Медицина, 1983. - pp. 208-211 [Russian]
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© Collected Ruslan Anatolievich Kiper, burewestnik@mail.ru